The Powerhouse: Caffeine, Creatine, and Athletic Performance

Study explores if creatine nitrate & caffeine improve exercise and focus in resistance-trained athletes.

NYB Team
By NYB Team
Mar 7, 2024
The Powerhouse: Caffeine, Creatine, and Athletic Performance

Optimizing athletic performance involves various strategies, including training and supplementation. Athletes are constantly seeking that extra edge, and supplements like caffeine and creatine have been popular choices. But with so much conflicting information, what truly works? This blog dives into the science behind these supplements and explores the potential of creatine nitrate, a newcomer to the game.The study investigated the effects of creatine nitrate and caffeine, alone and combined, on exercise performance and cognitive function in resistance-trained athletes. Twelve male athletes participated in a double-blind, randomised crossover trial, consuming creatine nitrate (5g/day), caffeine (400mg/day), or a combination of both for seven days. Researchers assessed cognitive function, cardiovascular responses, and performance in standardized resistance exercises (bench and leg press) and an anaerobic power test. The key question was whether these supplements, individually or together, would enhance physical output or mental focus during exercise.

Caffeine: The Focus Fighter

Caffeine's reputation for boosting alertness is well-deserved. Studies show it improves both physical performance and mental focus. It works by mimicking adenosine, a molecule that promotes sleepiness. By attaching to adenosine receptors, caffeine blocks the feeling of fatigue and enhances neural activity. This translates to increased strength, endurance, and sharper reflexes – perfect for sports demanding quick thinking and sustained focus.

Creatine: The Replenishing Rocket Fuel

Creatine is a champion in the world of sports nutrition. Its role in rapidly restoring ATP, the energy currency in cells, is well established. This translates to improved power output, allowing athletes to train harder and for longer. Studies also suggest creatine benefits brain function, especially during demanding activities.

Creatine Nitrate: The New Kid on the Block

Creatine nitrate combines the benefits of creatine with the potential for enhanced nitric oxide production. Nitric oxide plays a crucial role in blood flow, muscle oxygenation, and nutrient delivery. While research is ongoing, initial studies suggest creatine nitrate may improve circulation, muscle creatine levels, and even strength performance.

Combined Power or Conflicting Effects?

Some studies suggest a potential synergy, while others raise concerns about conflicting effects on muscle relaxation and digestion. The current research indicates that while both improve performance individually, their combined effects during resistance training require further investigation.

The Bottom Line

Caffeine and creatine are well-supported ergogenic aids, meaning they enhance performance. Creatine nitrate shows promise, but more research is needed. This study aimed to see if a seven-day, high-dose regimen of these supplements alone or combined could improve performance and focus in resistance-trained athletes. It also assessed their impact on cardiovascular health and blood chemistry. The results will be explored in a future blog, so stay tuned to see if the combined power of caffeine and creatine nitrate lives up to the hype!


Mabrey, G.; Koozehchian, M.S.; Newton, A.T.; Naderi, A.; Forbes, S.C.; Haddad, M. The Effect of Creatine Nitrate and Caffeine Individually or Combined on Exercise Performance and Cognitive Function: A Randomized, Crossover, Double-Blind, Placebo-Controlled Trial. Nutrients 2024, 16, 766.