Polyphenols, divided into four classes, boast antioxidant properties that can enhance our body's natural defenses. Research suggests that daily consumption of these compounds for at least three days before and after intense exercise may aid in recovering from muscle damage. However, the effectiveness of polyphenol supplements depends on their source and how they are processed. Information about these factors is often lacking in studies, making the quest for optimal conditions an ongoing challenge.

A substantial body of evidence supporting the role of polyphenols in reducing oxidative stress and inflammation is discussed below.

Montmorency tart cherry (TC) has emerged as a promising natural aid for post-exercise recovery. Whether consumed as a beverage or concentrate, TC is rich in anthocyanin polyphenols. Research suggests its positive impact on muscle recovery and function following various exercise types, including resistance-based, repeated sprints, and endurance activities, in both trained and untrained individuals. Additionally, TC intake is associated with reduced post-exercise muscle soreness and inflammation. For optimal results, a TC drink containing around 600 mg of polyphenols should be consumed twice daily for at least three days before exercise. Overall, TC shows great potential for athletes seeking enhanced recovery across different exercise modalities.

Pomegranate (POM) is rich in polyphenols, particularly ellagitannins and anthocyanins, known for their potential health benefits. POM has historically been used for treating inflammatory conditions and has demonstrated effects in reducing cancer proliferation, improving cardiovascular markers, and reducing inflammation in the gut and joints. In the context of exercise recovery, POM has shown promise, particularly in resistance-based exercise. Studies suggest that regular consumption of POM juice or concentrate for several days before exercise can enhance post-exercise muscle recovery and may reduce muscle soreness, although its effects in trained individuals might be exercise-specific. POM's impact on inflammation and blood vessel function provides potential mechanisms for these improvements. However, its effects on endurance exercise recovery remain unexplored, and individual training status could influence its effectiveness.

Blueberries are rich in anthocyanin polyphenols, and have shown potential in improving strength recovery after resistance-based exercise and enhancing muscle function following exhaustive endurance exercise. However, their consumption hasn't consistently reduced blood markers of muscle damage or inflammation, except for a decrease in IL-6 in sedentary adults. Polyphenols in blueberries might impact blood flow by inhibiting enzymes related to nitric oxide bioavailability, potentially speeding up lactate clearance and recovery. The required dose of blueberries for positive effects varies across studies, with the minimum effective dose being 600 mg of polyphenols, administered on the exercise day and for two days post-exercise. Further research is necessary to confirm these findings.

In conclusion, polyphenols, abundant in various fruits like blueberries and pomegranates, hold promise in enhancing post-exercise recovery. They appear to positively impact strength recovery and muscle function, especially following resistance-based and endurance exercises. While their effects on inflammation and muscle damage markers have been inconsistent, polyphenols may influence blood flow, potentially accelerating recovery processes. The optimal dosage and precise mechanisms are still subjects of ongoing research.

Stay tuned for more information on polyphenols in the coming weeks as we delve deeper into their role in optimizing post-exercise recovery and overall health.

Credits 

• O’Connor, E.; Mündel, T.; Barnes, M.J. Nutritional Compounds to Improve Post-Exercise Recovery. Nutrients 2022, 14, 5069. https://doi.org/10.3390/nu14235069

• Rice-Evans, C.A.; Miller, N.J.; Paganga, G. Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free Radic. Biol. Med. 1996, 20, 933–956. 

• Myburgh, K.H. Polyphenol supplementation: Benefits for exercise performance or oxidative stress? Sports Med. 2014, 44, 57–70.

• Sumners, D.P.; Dyer, A.; Fox, P.; Mileva, K.N.; Bowtell, J. Montmorency cherry juice reduces muscle damage caused by intensive strength exercise. Med. Sci. Sports Exerc. 2011, 43, 1544–1551.

• Connolly, D.; McHugh, M.; Padilla-Zakour, O. Efficacy of a tart cherry juice blend in preventing the symptoms of muscle damage. Br. J. Sports Med. 2006, 40, 679–683. 

• Bell, P.G.; Stevenson, E.; Davison, G.W.; Howatson, G. The effects of montmorency tart cherry concentrate supplementation on recovery following prolonged, intermittent exercise. Nutrients 2016, 8, 441.

• Brown, M.A.; Stevenson, E.J.; Howatson, G. Montmorency tart cherry (Prunus cerasus L.) supplementation accelerates recovery from exercise-induced muscle damage in females. Eur. J. Sport Sci. 2019, 19, 95–102.  

• Howatson, G.; McHugh, M.P.; Hill, J.; Brouner, J.; Jewell, A.; Van Someren, K.A.; Shave, R.; Howatson, S. Influence of tart cherry juice on indices of recovery following marathon running. Scand. J. Med. Sci. Sports 2010, 20, 843–852.  

• Bell, P.G.; Walshe, I.H.; Davison, G.W.; Stevenson, E.J.; Howatson, G. Recovery facilitation with Montmorency cherries following high-intensity, metabolically challenging exercise. Appl. Physiol. Nutr. Metab. 2015, 40, 414–423.

• Levers, K.; Dalton, R.; Galvan, E.; Goodenough, C.; O’Connor, A.; Simbo, S.; Barringer, N.; Mertens-Talcott, S.U.; Rasmussen, C.; Greenwood, M. Effects of powdered Montmorency tart cherry supplementation on an acute bout of intense lower body strength exercise in resistance trained males. J. Int. Soc. Sports Nutr. 2015, 12, 41.

• Levers, K.; Dalton, R.; Galvan, E.; O’Connor, A.; Goodenough, C.; Simbo, S.; Mertens-Talcott, S.U.; Rasmussen, C.; Greenwood, M.; Riechman, S. Effects of powdered Montmorency tart cherry supplementation on acute endurance exercise performance in aerobically trained individuals. J. Int. Soc. Sports Nutr. 2016, 13, 22.

• Seeram, N.P.; Lee, R.; Heber, D. Bioavailability of ellagic acid in human plasma after consumption of ellagitannins from pomegranate (Punica granatum L.) juice. Clin. Chim. Acta 2004, 348, 63–68. 

• Ismail, T.; Sestili, P.; Akhtar, S. Pomegranate peel and fruit extracts: A review of potential anti-inflammatory and anti-infective effects. J. Ethnopharmacol. 2012, 143, 397–405. 

• Adams, L.S.; Zhang, Y.; Seeram, N.P.; Heber, D.; Chen, S. Pomegranate ellagitannin–derived compounds exhibit antiproliferative and antiaromatase activity in breast cancer cells in vitro. Cancer Prev. Res. 2010, 3, 108–113.

• Aviram, M.; Rosenblat, M.; Gaitini, D.; Nitecki, S.; Hoffman, A.; Dornfeld, L.; Volkova, N.; Presser, D.; Attias, J.; Liker, H. Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation. Clin. Nutr. 2004, 23, 423–433. 

• Shukla, M.; Gupta, K.; Rasheed, Z.; Khan, K.A.; Haqqi, T.M. Consumption of hydrolyzable tannins-rich pomegranate extract suppresses inflammation and joint damage in rheumatoid arthritis. Nutrition 2008, 24, 733–743.

• Sergent, T.; Piront, N.; Meurice, J.; Toussaint, O.; Schneider, Y.-J. Anti-inflammatory effects of dietary phenolic compounds in an in vitro model of inflamed human intestinal epithelium. Chem.-Biol. Interact. 2010, 188, 659–667.  

• Ammar, A.; Turki, M.; Hammouda, O.; Chtourou, H.; Trabelsi, K.; Bouaziz, M.; Abdelkarim, O.; Hoekelmann, A.; Ayadi, F.; Souissi, N. Effects of pomegranate juice supplementation on oxidative stress biomarkers following weightlifting exercise. Nutrients 2017, 9, 819.  [Green Version]

• Trombold, J.R.; Barnes, J.N.; Critchley, L.; Coyle, E.F. Ellagitannin consumption improves strength recovery 2–3 d after eccentric exercise. Med. Sci. Sports Exerc. 2010, 42, 493–498.

• Trombold, J.R.; Reinfeld, A.S.; Casler, J.R.; Coyle, E.F. The effect of pomegranate juice supplementation on strength and soreness after eccentric exercise. J. Strength Cond. Res. 2011, 25, 1782–1788. 

• Machin, D.R.; Christmas, K.M.; Chou, T.-H.; Hill, S.C.; Van Pelt, D.W.; Trombold, J.R.; Coyle, E.F. Effects of differing dosages of pomegranate juice supplementation after eccentric exercise. Physiol. J. 2014, 2014, 271959.

• Roelofs, E.J.; Smith-Ryan, A.E.; Trexler, E.T.; Hirsch, K.R.; Mock, M.G. Effects of pomegranate extract on blood flow and vessel diameter after high-intensity exercise in young, healthy adults. Eur. J. Sport Sci. 2017, 17, 317–325.  

• Trexler, E.T.; Smith-Ryan, A.E.; Melvin, M.N.; Roelofs, E.J.; Wingfield, H.L. Effects of pomegranate extract on blood flow and running time to exhaustion. Appl. Physiol. Nutr. Metab. 2014, 39, 1038–1042.

• Prior, R.L.; Cao, G.; Martin, A.; Sofic, E.; McEwen, J.; O’Brien, C.; Lischner, N.; Ehlenfeldt, M.; Kalt, W.; Krewer, G. Antioxidant capacity as influenced by total phenolic and anthocyanin content, maturity, and variety of Vaccinium species. J. Agric. Food Chem. 1998, 46, 2686–2693. 

• McLeay, Y.; Barnes, M.J.; Mundel, T.; Hurst, S.M.; Hurst, R.D.; Stannard, S.R. Effect of New Zealand blueberry consumption on recovery from eccentric exercise-induced muscle damage. J. Int. Soc. Sports Nutr. 2012, 9, 19.

• Brandenburg, J.P.; Giles, L.V. Four days of blueberry powder supplementation lowers the blood lactate response to running but has no effect on time-trial performance. Int. J. Sport Nutr. Exerc. Metab. 2019, 29, 636–642.  

• McAnulty, L.S.; Nieman, D.C.; Dumke, C.L.; Shooter, L.A.; Henson, D.A.; Utter, A.C.; Milne, G.; McAnulty, S.R. Effect of blueberry ingestion on natural killer cell counts, oxidative stress, and inflammation prior to and after 2.5 h of running. Appl. Physiol. Nutr. Metab. 2011, 36, 976–984.  

• Nieman, D.C.; Gillitt, N.D.; Shanely, R.A.; Dew, D.; Meaney, M.P.; Luo, B. Vitamin D2 supplementation amplifies eccentric exercise-induced muscle damage in NASCAR pit crew athletes. Nutrients 2013, 6, 63–75.

• Bloedon, T.K.; Braithwaite, R.E.; Carson, I.A.; Klimis-Zacas, D.; Lehnhard, R.A. Impact of anthocyanin-rich whole fruit consumption on exercise-induced oxidative stress and inflammation: A systematic review and meta-analysis. Nutr. Rev. 2019, 77, 630–645.  

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